Studimet e fundit sugjerojn\u00eb q\u00eb vaksinat e ARNi-s\u00eb kund\u00ebr COVID-19 mund t\u00eb luajn\u00eb nj\u00eb rol t\u00eb habitsh\u00ebm n\u00eb trajtimin e kancerit, duke p\u00ebrmir\u00ebsuar potencialisht mbijetes\u00ebn p\u00ebr pacient\u00ebt q\u00eb i n\u00ebnshtrohen imunoterapis\u00eb p\u00ebr kancer t\u00eb avancuar t\u00eb mushk\u00ebrive dhe l\u00ebkur\u00ebs. Dy studime t\u00eb m\u00ebdha nga Universiteti i Florid\u00ebs (UF) dhe Qendra e Kancerit MD Anderson, t\u00eb prezantuara n\u00eb Kongresin e Shoq\u00ebris\u00eb Evropiane p\u00ebr Onkologji Mjek\u00ebsore (ESMO) 2025, nxjerrin n\u00eb pah potencialin transformues t\u00eb k\u00ebtyre vaksinave p\u00ebrtej mbrojtjes kund\u00ebr viruseve. Studimet analizuan t\u00eb dh\u00ebna nga m\u00eb shum\u00eb se 1,000 pacient\u00eb t\u00eb trajtuar midis viteve 2019 dhe 2023 dhe zbuluan se pacient\u00ebt q\u00eb mor\u00ebn nj\u00eb vaksin\u00eb mRNA brenda 100 dit\u00ebve nga fillimi i trajtimit me frenues t\u00eb pikave t\u00eb kontrollit imunitar mbijetuan duksh\u00ebm m\u00eb gjat\u00eb.<\/p>\n
N\u00eb kancerin e mushk\u00ebrive me qeliza jo t\u00eb vogla: Midis 180 pacient\u00ebve q\u00eb mor\u00ebn nj\u00eb vaksin\u00eb me ARNi pran\u00eb fillimit t\u00eb imunoterapis\u00eb, mbijetesa mesatare ishte 37.3 muaj \u2013 pothuajse dyfishi i 20.6 muajve t\u00eb v\u00ebrejtur te 704 pacient\u00eb q\u00eb nuk e mor\u00ebn vaksin\u00ebn. N\u00eb melanom\u00ebn metastatike: Nga 43 pacient\u00ebt e vaksinuar, mbijetesa mesatare varionte nga 30 deri n\u00eb 40 muaj, krahasuar me 26,7 muaj p\u00ebr 167 pacient\u00eb t\u00eb pavaksinuar. Disa pacient\u00eb t\u00eb vaksinuar ishin ende gjall\u00eb n\u00eb koh\u00ebn e mbledhjes s\u00eb t\u00eb dh\u00ebnave, duke sugjeruar se ndikimi i mundsh\u00ebm mund t\u00eb jet\u00eb edhe m\u00eb i madh.<\/p>\n
N\u00eb tumoret imunorezistente: P\u00ebrfitimet m\u00eb mbres\u00ebl\u00ebn\u00ebse u pan\u00eb te pacient\u00ebt me tumore q\u00eb jan\u00eb zakonisht rezistent\u00eb ndaj imunoterapis\u00eb. K\u00ebta pacient\u00eb p\u00ebrjetuan nj\u00eb p\u00ebrmir\u00ebsim deri n\u00eb pes\u00ebfish n\u00eb mbijetes\u00ebn e p\u00ebrgjithshme 3-vje\u00e7are. \u00cbsht\u00eb gjithashtu interesante q\u00eb vaksinat q\u00eb synojn\u00eb patogjen\u00eb t\u00eb tjer\u00eb, si\u00e7 jan\u00eb gripi ose pneumonia, nuk kan\u00eb treguar efekte t\u00eb ngjashme.<\/p>\n
Studimet paraklinike te minjt\u00eb dhe analizat e t\u00eb dh\u00ebnave t\u00eb pacient\u00ebve ofrojn\u00eb nj\u00eb shpjegim t\u00eb mundsh\u00ebm p\u00ebr efektin e vaksinave kund\u00ebr COVID-19 te kanceri: vaksinat e ARNi-s\u00eb veprojn\u00eb si nj\u00eb \u201calarm\u201d p\u00ebr sistemin imunitar, duke mobilizuar qelizat imune dhe duke rritur shprehjen tumorale t\u00eb PD-L1, nj\u00eb protein\u00eb q\u00eb tumoret p\u00ebrdorin p\u00ebr t\u00eb shmangur sulmet e sistemit imunitar. Frenuesit e pikave t\u00eb kontrollit imunitar mund ta bllokojn\u00eb m\u00eb pas k\u00ebt\u00eb mbrojtje, duke i lejuar p\u00ebrs\u00ebri sistemit imunitar t\u00eb veproj\u00eb \u201ci pashqet\u00ebsuar\u201d kund\u00ebr kancerit.<\/p>\n
Elias Sayour, M.D., Ph.D., i UF-s\u00eb, vuri n\u00eb dukje se rezultati i ngjan atij t\u00eb vaksinave eksperimentale \u201cjospecifike\u201d t\u00eb ARNi-s\u00eb t\u00eb zhvilluara n\u00eb laboratorin e tij, t\u00eb cilat mund t\u00eb forcojn\u00eb p\u00ebrgjigjet imune kund\u00ebr kancerit pa synuar nj\u00eb protein\u00eb specifike t\u00eb kancerit. Gjetjet sugjerojn\u00eb q\u00eb, potencialisht, n\u00eb t\u00eb ardhmen, k\u00ebto vaksina t\u00eb disponueshme gjer\u00ebsisht dhe me kosto t\u00eb ul\u00ebt mund t\u00eb p\u00ebrdoren p\u00ebr t\u00eb p\u00ebrmir\u00ebsuar efektivitetin e imunoterapis\u00eb. Studiuesit tani po planifikojn\u00eb nj\u00eb prov\u00eb klinike shum\u00ebqendrore t\u00eb Faz\u00ebs III p\u00ebr t\u00eb konfirmuar k\u00ebto rezultate dhe p\u00ebr t\u00eb p\u00ebrcaktuar n\u00ebse vaksinat COVID mRNA mund t\u00eb b\u00ebhen nj\u00eb terapi standarde shtes\u00eb p\u00ebr pacient\u00ebt q\u00eb marrin frenues t\u00eb pikave t\u00eb kontrollit imunitar.<\/p>\n
\u201cKy zbulim mund t\u00eb revolucionarizoj\u00eb kujdesin onkologjik\u201d, tha Dr. Sayour. \u201cN\u00ebse konfirmohet, do t\u00eb hap\u00eb rrug\u00ebn p\u00ebr zhvillimin e vaksinave t\u00eb bazuara n\u00eb mRNA q\u00eb rrisin aft\u00ebsin\u00eb e sistemit imunitar p\u00ebr t\u00eb luftuar kancerin, duke u dh\u00ebn\u00eb potencialisht pacient\u00ebve koh\u00eb shtes\u00eb t\u00eb vlefshme\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"
Studimet e fundit sugjerojn\u00eb q\u00eb vaksinat e ARNi-s\u00eb kund\u00ebr COVID-19 mund t\u00eb luajn\u00eb nj\u00eb rol t\u00eb habitsh\u00ebm n\u00eb trajtimin e kancerit, duke p\u00ebrmir\u00ebsuar potencialisht mbijetes\u00ebn p\u00ebr pacient\u00ebt q\u00eb i n\u00ebnshtrohen imunoterapis\u00eb p\u00ebr kancer t\u00eb avancuar t\u00eb mushk\u00ebrive dhe l\u00ebkur\u00ebs. Dy studime t\u00eb m\u00ebdha nga Universiteti i Florid\u00ebs (UF) dhe Qendra e Kancerit MD Anderson, t\u00eb<\/p>\n","protected":false},"author":1,"featured_media":12420,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":{"0":"post-12419","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-lifestyle"},"_links":{"self":[{"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/posts\/12419","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/comments?post=12419"}],"version-history":[{"count":1,"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/posts\/12419\/revisions"}],"predecessor-version":[{"id":12421,"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/posts\/12419\/revisions\/12421"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/media\/12420"}],"wp:attachment":[{"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/media?parent=12419"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/categories?post=12419"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/tags?post=12419"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}