{"id":12584,"date":"2025-11-02T11:07:30","date_gmt":"2025-11-02T11:07:30","guid":{"rendered":"https:\/\/revistatrend.com\/?p=12584"},"modified":"2025-11-02T11:07:30","modified_gmt":"2025-11-02T11:07:30","slug":"floket-e-thinjur-mund-te-jene-shenje-se-trupi-po-mbrohet-nga-kanceri","status":"publish","type":"post","link":"https:\/\/revistatrend.com\/index.php\/2025\/11\/02\/floket-e-thinjur-mund-te-jene-shenje-se-trupi-po-mbrohet-nga-kanceri\/","title":{"rendered":"Flok\u00ebt e thinjur mund t\u00eb jen\u00eb shenj\u00eb se trupi po mbrohet nga kanceri"},"content":{"rendered":"

Shkenc\u00ebtar\u00ebt po zbulojn\u00eb se si qelizat burimore t\u00eb folikulave t\u00eb flok\u00ebve eliminojn\u00eb qelizat e rrezikshme dhe zvog\u00eblojn\u00eb rrezikun e melanom\u00ebs<\/strong>. Flok\u00ebt e thinjur zakonisht shihen si shenj\u00eb plakjeje, por nj\u00eb studim i ri japonez, si\u00e7 shkruan <\/span>ScienceAlert<\/em>, sugjeron se ato mund t\u00eb jen\u00eb n\u00eb fakt\u00a0<\/span>tregues se trupi yn\u00eb po mbrohet natyrsh\u00ebm nga kanceri<\/strong>.<\/span><\/p>\n

Nj\u00eb studim i kryer tek minjt\u00eb ka treguar se\u00a0trupi i njeriut ka evoluar nj\u00eb mekaniz\u00ebm p\u00ebr t\u00eb eliminuar qelizat q\u00eb rrezikojn\u00eb t\u00eb formojn\u00eb tumore<\/strong>, edhe n\u00ebse kjo n\u00ebnkupton humbjen e ngjyr\u00ebs s\u00eb flok\u00ebve.<\/p>\n

Roli i qelizave burimore<\/span><\/div>\n

Qelizat tona ekspozohen \u00e7do dit\u00eb ndaj faktor\u00ebve t\u00eb ndrysh\u00ebm mjedisor\u00eb q\u00eb mund t\u00eb d\u00ebmtojn\u00eb ADN-n\u00eb.\u00a0Qelizat e l\u00ebkur\u00ebs<\/strong>\u00a0jan\u00eb ve\u00e7an\u00ebrisht t\u00eb ndjeshme, sepse veprojn\u00eb si linja e par\u00eb mbrojt\u00ebse p\u00ebr organet e brendshme. D\u00ebmtimi i ADN-s\u00eb mund t\u00eb kontribuoj\u00eb si n\u00eb\u00a0plakjen e qelizave<\/strong>, ashtu edhe n\u00eb\u00a0zhvillimin e kancerit<\/strong>.<\/p>\n

Edhe pse ekspert\u00ebt ende nuk i kuptojn\u00eb plot\u00ebsisht t\u00eb gjith\u00eb mekanizmat q\u00eb lidhin d\u00ebmtimin e ADN-s\u00eb me shenjat fizike t\u00eb plakjes, ky studim sjell\u00a0t\u00eb dh\u00ebna t\u00eb reja interesante<\/strong>.<\/p>\n

Studiuesit u p\u00ebrqendruan n\u00eb\u00a0melanom\u00ebn<\/strong>, nj\u00eb form\u00eb kanceri q\u00eb zakonisht shfaqet n\u00eb l\u00ebkur\u00eb dhe q\u00eb lind nga\u00a0melanocitet,\u00a0<\/strong>qelizat q\u00eb prodhojn\u00eb\u00a0melanin\u00ebn<\/strong>, pigmentin p\u00ebrgjegj\u00ebs p\u00ebr ngjyr\u00ebn e l\u00ebkur\u00ebs dhe t\u00eb flok\u00ebve. Melanocitet zhvillohen nga\u00a0qelizat burimore t\u00eb melanociteve (McSCs)<\/strong>\u00a0q\u00eb ndodhen n\u00eb folikulat e flok\u00ebve, ku ato rregullisht rigjenerojn\u00eb pigmentimin e l\u00ebkur\u00ebs dhe t\u00eb flok\u00ebve, transmeton Telegrafi.<\/p>\n

<\/p>\n
Studimi tek minjt\u00eb<\/span><\/div>\n

<\/ins><\/div>\n

Duke studiuar minjt\u00eb, shkenc\u00ebtar\u00ebt analizuan\u00a0ekspresionin e gjeneve<\/strong>\u00a0p\u00ebr t\u00eb ndjekur fatin e qelizave McSC pas d\u00ebmtimeve t\u00eb ndryshme t\u00eb ADN-s\u00eb. N\u00eb rastin e\u00a0d\u00ebmtimeve t\u00eb quajtura \u201cthyerje t\u00eb dyfishta t\u00eb zinxhirit\u201d<\/strong>, ku t\u00eb dy zinxhir\u00ebt e ADN-s\u00eb nd\u00ebrpriten, qelizat McSC\u00a0u diferencuan n\u00eb m\u00ebnyr\u00eb t\u00eb pakthyeshme<\/strong>\u00a0dhe m\u00eb pas u zhduk\u00ebn. Si rezultat,\u00a0flok\u00ebt e minjve u thinj\u00ebn<\/strong>.<\/p>\n

\"\"<\/div>\n

<\/ins><\/p>\n

Ky proces quhet\u00a0\u201cdiferencim i induktuar nga plakja\u201d<\/strong>\u00a0ose\u00a0plakje-diferencim<\/em>\u00a0dhe bazohet n\u00eb\u00a0aktivizimin e rrug\u00ebs sinjalizuese p53\u2013p21<\/strong>, e cila rregullon ciklin qelizor. N\u00eb k\u00ebt\u00eb m\u00ebnyr\u00eb, trupi eliminon qelizat q\u00eb mund t\u00eb b\u00ebhen kancerogjene, edhe pse kjo sjell humbjen e ngjyr\u00ebs s\u00eb flok\u00ebve.<\/p>\n

Megjithat\u00eb,\u00a0ekspozimi ndaj disa kancerogjen\u00ebve<\/strong>\u00a0shkaktoi nj\u00eb reagim t\u00eb ndrysh\u00ebm. Minjt\u00eb u ekspozuan ndaj\u00a0rrezatimit UVB<\/strong>\u00a0dhe ndaj\u00a07,12-dimetilbenz(a)antracenit (DMBA)<\/strong>, nj\u00eb kancerogjen i fuqish\u00ebm q\u00eb p\u00ebrdoret shpesh n\u00eb k\u00ebrkime p\u00ebr t\u00eb induktuar tumore. Studimi tregoi se qelizat McSC\u00a0e anashkaluan procesin e diferencimit<\/strong>\u00a0q\u00eb ndodh pas thyerjeve t\u00eb dyfishta, edhe pse kishin p\u00ebsuar d\u00ebmtime n\u00eb ADN.<\/p>\n

\"\"<\/div>\n
Kancerogjen\u00ebt mund t\u00eb ndryshojn\u00eb fatin e qelizave<\/span><\/div>\n

<\/ins><\/p>\n

K\u00ebto gjetje sugjerojn\u00eb se,\u00a0nganj\u00ebher\u00eb, \u201ct\u00eb dish kur t\u00eb ndalesh\u201d mund t\u00eb jet\u00eb \u00e7el\u00ebsi i mbijetes\u00ebs<\/strong>. P\u00ebr qelizat McSC, t\u00ebrheqja dhe nd\u00ebrprerja e funksionit si p\u00ebrgjigje ndaj d\u00ebmtimit t\u00eb ADN-s\u00eb mund t\u00eb jet\u00eb mbrojt\u00ebse edhe pse humbasin pigmentin,\u00a0trupi mbrohet nga kanceri i l\u00ebkur\u00ebs<\/strong>.<\/p>\n

Kur qelizat McSC u ekspozuan ndaj UVB ose DMBA, ato\u00a0ruajt\u00ebn aft\u00ebsin\u00eb p\u00ebr vet\u00eb-rigjenerim<\/strong>\u00a0dhe vazhduan t\u00eb klonohen. Ky proces mb\u00ebshtetet nga\u00a0faktori i qelizave burimore (FM\u015a)<\/strong>, nj\u00eb\u00a0citokin<\/strong>\u00a0q\u00eb udh\u00ebheq melanocitet drejt vendndodhjes s\u00eb tyre n\u00eb l\u00ebkur\u00eb. FM\u015a gjithashtu\u00a0pengon plakjen<\/strong>, q\u00eb do t\u00eb thot\u00eb se qelizat McSC t\u00eb d\u00ebmtuara\u00a0mund t\u00eb mbijetojn\u00eb dhe t\u00eb ndahen m\u00eb tej<\/strong>, duke\u00a0rritur rrezikun e kancerit<\/strong>.<\/p>\n

\u201cE nj\u00ebjta popullat\u00eb qelizash burimore mund t\u00eb ndjek\u00eb fate t\u00eb kund\u00ebrta \u2013 shterim ose p\u00ebrhapje \u2013 n\u00eb var\u00ebsi t\u00eb llojit t\u00eb stresit dhe sinjaleve nga mikroambienti\u201d, shpjegon autorja kryesore\u00a0Emi Nishimura<\/strong>, biologe n\u00eb Universitetin e Tokios.<\/p>\n

Ajo shton se ky zbulim\u00a0ndryshon m\u00ebnyr\u00ebn se si e kuptojm\u00eb flokun e thinjur dhe melanom\u00ebn<\/strong>\u00a0\u2013 jo si ngjarje t\u00eb ndara, por si\u00a0rezultate t\u00eb ndryshme t\u00eb p\u00ebrgjigjeve t\u00eb qelizave burimore ndaj stresit<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Shkenc\u00ebtar\u00ebt po zbulojn\u00eb se si qelizat burimore t\u00eb folikulave t\u00eb flok\u00ebve eliminojn\u00eb qelizat e rrezikshme dhe zvog\u00eblojn\u00eb rrezikun e melanom\u00ebs. Flok\u00ebt e thinjur zakonisht shihen si shenj\u00eb plakjeje, por nj\u00eb studim i ri japonez, si\u00e7 shkruan ScienceAlert, sugjeron se ato mund t\u00eb jen\u00eb n\u00eb fakt\u00a0tregues se trupi yn\u00eb po mbrohet natyrsh\u00ebm nga kanceri. Nj\u00eb studim<\/p>\n","protected":false},"author":1,"featured_media":12585,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":{"0":"post-12584","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-lifestyle"},"_links":{"self":[{"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/posts\/12584","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/comments?post=12584"}],"version-history":[{"count":1,"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/posts\/12584\/revisions"}],"predecessor-version":[{"id":12586,"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/posts\/12584\/revisions\/12586"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/media\/12585"}],"wp:attachment":[{"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/media?parent=12584"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/categories?post=12584"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistatrend.com\/index.php\/wp-json\/wp\/v2\/tags?post=12584"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}